Fish, Mice, &
Fish, Mice, & Zombies
BY REID GUDGER & CHRIS KNOLLMAN
Tetrodotoxin (TTX) is a potent neurotoxin found in fish and other aquatic animals. Popular culture would have you believe that TTX could be used to simulate death, even create zombies, but is this science fiction or fact? UNC Asheville seniors Reid and Chris investigate!
This episode was produced as part of an upper level course on Neuropharmacology taught by Angel Kaur during Fall 2018 at UNC Asheville.
Abal, P., et al. Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL). Toxins 9, 75 (2017).
Lago, J., et al. Tetrodotoxin, an Extremely Potent Marine Neurotoxin: Distribution, Toxicity, Origin and Therapeutical Uses. Mar. Drugs, 13, 6384-6406 (2015).
Moczydlowski, E.G. The molecular mystique of tetrodotoxin. Toxicon, 63, 165-183 (2013).
Yoshida, S. Tetrodotoxin-resistant sodium channels. Cell. Mol. Neurobiol.14, 227-244 (1994).
Writers and Hosts: Reid Gudger and Chris Knollman
Scientific Research: Reid Gudger and Chris Knollman
Recording Assistance: Dean Merritt
Additional Editing: Angel Kaur
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