Neuroscience is a Language,
Can Word Games Help?

Presenting Forbidden Neurds: A Neuroscience Word Game


You already know that I am neuroscientist.
What you may not know is, I also love board games.

When I first began teaching introductory biology courses, I found myself telling students that learning cell and molecular biology is very much like learning a new language. It would take time and practice, in many different forms, to gain fluency. Moreover, just learning the meaning of the words wasn’t enough. Language is complex, with the same words taking on varied meanings based on the context. In fact, I wanted to actively demotivate rote memorization of definitions as a study tactic.

Thus, Forbidden Neurds was born.

Similar in gameplay to popular games like Secret Word, Catchphrase or Taboo, Forbidden Neurds tasks students with scoring points by getting their team to guess the Neuroscience Word without using any of the Forbidden Words. 

A primary goal of the game design is to promote deeper understanding of the terminology rather than incentivizing simply learning the definitions that populate the indexes of all undergraduate textbooks. How do I do this? Simple – I made keywords from the formal definition of neuroscience terms part of the Forbidden Word list!

Let me give you an example

A new term students may encounter in an introductory neuroscience course is the blood brain barrier (BBB).

This term describes an important structure in the brain that is used to protect the brain from the ever-changing content of our blood. Why is this important? The primary way in which our neurons talk to each other is through changes in the concentration of specific molecules (charged ions) within individual cells. So, for our brain to function properly, there must be somewhat steady levels of ion concentrations both inside and outside the neurons under normal conditions. There are many structures in the brain that work to keep the concentrations of important ions (like sodium and potassium) relatively constant within the brain, and the blood brain barrier is a vital part of this process.

Figure 1: Differences in capillary structure in the body (left) vs. in the brain (right). Made using BioRender

Figure 1: Differences in capillary structure in the body (left) vs. in the brain (right). Made using BioRender

The BBB is formed through in the blood capillary structures in the brain. Capillaries are small blood vessels that carry blood to and from tissues, and cells use these capillaries to receive more nutrients and get rid of waste by moving molecules through the capillary membranes. Unlike capillaries in the rest of the body, those in the brain have smaller and fewer openings in their membranes, creating less opportunities for molecules to freely pass from the blood into the brain (illustrated in the figure to the right).

Understanding what makes the blood brain barrier work is particularly important in the field of Neuropharmacology (one of my course offerings), because any medication you take must be able to pass through the barrier to be able to treat your symptoms. When presenting this concept in class, I highlight the importance of maintaining steady levels of ions in the brain with a news story. In 2013, a 19-year-old was dared by his friends to drink a quart of soy sauce, a game that ended with him going into a coma because of the salt imbalance in his blood stream! Thankfully, he survived, and did not suffer any long-term damage from the incident. This story can anchor student’s understanding of structures like the blood brain barrier, and why protecting your brain from your blood can be a matter of life and death!

So, how can we encourage students to learn the concept of the blood brain barrier through a game like
Forbidden Neurds?

The definition of the BBB in the textbook I used in this course is:

Figure 2: Bear “Neuroscience: Exploring the Brain” 3rd Edition, Lippincott Williams and Wilkins

Based on this definition, I created the game card as shown. So, the student with the card has to come with a new way to describe this structure, perhaps “it’s the thing that keeps your neurons safe from things that you drink!” By asking students to creatively engage with new terminology through game play, we can promote positive associations with learning as a fun activity, that is rewarded through bonus points, and the praises of classmates marveling at an expertly designed clue. This gamification also forces students to think outside of the traditional confines of science, an important skill in effective science communication.

Figure 3: A Sample Forbidden Neurds game card

Some Strategies for Implementation

Game cards from Neuroscience taboo strewn on a table
  1. Build your Neuroscience term list from the bolded terms in your course textbook. These words are often the novel words in the chapter, and emphasizing them will allow your students to build their confidence in navigating the course material

  2. Strategically chose the Forbidden Words to leave some options open for students to create an effective clue if they put some thought into it. For example, if the term has an opposite, you may leave that off the card, so students can connect the terms together to offer their clue.

  3. To level up, share the learning goals of the game with students, and then ask them to generate the cards. This will help them deconstruct the notion of definition-based memorization on their own.
  4. Buy or print/cut actual game cards out. They don’t have to be perfect, but having something that resembles a real game adds a needed dose of whimsy to the activity! An easy strategy is to print multiple copies on different colored card stock to easily sort card decks.
  5. Set aside a whole class period for play. It seems dauting to lose instructional time, especially in an introductory survey course, but subbing in a game session in lieu of a formal review session ahead of an exam is a great way to achieve two learning goals with one activity. Students get to review terminology ahead of the exam, and because the class is engaged in active learning, you can address outstanding questions with individual students as need be.
  6. To level up, assign a nominal amount of bonus points to the game. For example, 1 point for playing, and 3 if you’re on the winning team. Assigning points to the game can increase student motivation to prepare for the game, which is an important stealth goal. Personal lesson: assigning too many points to the activity and only awarding them to the game winners can backfire, and cause students to feel disempowered in the process!

  7. Encourage students to keep recycling unguessed cards into the playing deck. When they finally get the answer, they organically start to discuss the card and why it was difficult to construct a clue to go with the card. This also creates a deeper learning experience, as students can get real time feedback on different ways to analyze unfamiliar words.

  8. Sometimes an entire group (or even an entire class) will swear up and down that they’ve never seen a term mentioned on the card. You can pause gameplay and discuss the concept with the whole class in a minilecture, or encourage the students to use the Forbidden words to make educated guesses. Either way, a higher percentage of student will have seen a higher percentage of the important terms, which will help their learning experience overall.

  9. If you do multiple rounds of gameplay over the semester (which I recommend), ask all students to participate in the first game day, but let them opt out on future game days if they wish. This structure can strike a good balance between asking students to step out of their comfort zone in a safe way (everyone has to play!), and empowering students by allowing them to make certain decisions about their learning (a strategy emphasized by Brett Jones in Motivating Students by Design).

My favorite part of the game play is observing students using popular culture references to nudge their teammates in the right direction. I found these instances very powerful, because the students were actively linking their current knowledge, thus far unlinked to science, with the course material. This led to deeper learning, and brought play back into the learning equation. Often students believe being in a science class has to be difficult and that creativity cannot make it easy or enjoyable. But this exercise proves otherwise. Students typically engage deeply with the game, investing in their team identity, and coming up with clever ways to get their teammates to the right answer. And they typically leave the class period energized by the experience.

Final Notes: Thinking Outside the Box

One day, a team that had opted out from the review game in my Introductory Neuroscience course requested a deck of playing cards anyway. When I asked why, they said they were using the game cards as complex flash cards. Rather than simply playing the game, this team was defining each set of words on the card, and trying to articulate the links between the different terms. I was impressed at their insight – the cards I had created were perfect for this type of application-based study strategy. As I left class, I made a note to myself to suggest this strategy with future cohorts in the class.

Want a pre-made set of printable cards for your Introductory Neuroscience or Introductory Cell and Molecular Biology course? Or just a template to make your own cards? Send me an email and I’ll share the requested resources!

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