Episode 6: Breathing New Life into DMT
BY MATTHEW EMRICH
DMT, or Dimethyltryptamine, is a drug most famous for its religious and recreational use, but can it be used for medical purposes? Join Matt as he dives into the effect of DMT on the brain, and especially in low-oxygen conditions.
This episode was produced as part of an upper level course on Neuropharmacology taught by Angel Kaur during Fall 2016 at UNC Asheville.
Szabo, A., et al. The Endogenous Hallucinogen and Trace Amine N,N,Dimethyltryptamine (DMT) Displays Potent Protective Effects against Hypoxia via Sigma-1 Receptor Activation in Human Primary iPSC-Derived Cortical Neurons and Microglia-Like Immune Cells. Front. Neurosci. 10, 1-11 (2016).
Frecska, E., Szabo, A., Winkelman, M., Luna, L. & McKenna, D. Possibly sigma-1 receptor mediated role of dimethyltryptamine in tissue protection, regeneration, and immunity. J. Neural Transm. 120(9), 1295-1303 (2013).
Gatch, M. B., Carbonaro, T., Rutledge, M. & Forster, M. Comparison of discriminative stimulus effects of dimethyltryptamine with different classes of psychoactive compounds in rats. Psychopharmacology 204, 715-724 (2009).
Writer and Host: Matthew Emrich
Sound Engineering: Jessica Fox and Angel Kaur
Scientific Research: Matthew Emrich
Additional Scientific Research: Caitlin Lahue
Web Content: Christopher Sabatini