Episode 18:
Exploring the Secrets of Lithium
Exploring the Secrets of Lithium
BY ALEXIS WHITESIDE, AUSTII BURRELL, KYLE LORENTZEN, & SAMANTHA HOFFMAN
In this episode, we dive into some secrets about Lithium that you may have otherwise not known, we sure didn’t until we did the research! From its beneficial effects, to the disorders it is used to alleviate, and its potential neurotoxicity – we use explanations of the drug’s history, neurological/biological mechanisms, and personal stories and experiences to give you all the information you need to know about the drug.
This episode was produced as part of an upper level course on Neuropharmacology taught by Angel Kaur during Fall 2020 at UNC Asheville.
Articles Referenced
- Altun, İ. K., Kılıç, N., Yıldızoğlu, E., & Atagün, M. İ. Lithium associated side effects and neurotoxicity: Is lithium neurotoxicity related to iron deposition? Psikiyatride Guncel Yaklasimlar, 11(2), 141-153. (2019).
- Dahan, A. et. al. Lithium Toxicity with Severe Bradycardia Post Sleeve Gastrectomy: a Case Report and Review of the Literature. Obesity Surgery. 735-738. (2019)
- Duffy, A., MD et al. History of the introduction of lithium into medicine and psychiatry: birth of modern psychopharmacology 1949. Canadian Journal of Psychiatry. 811 (2010).
- Edokpolo, O., Fyyaz, M. Lithium toxicity and neurologic effects: probable neuroleptic malignant syndrome resulting from lithium toxicity. Case Reports in Psychiatry. (2012)
- Hlaing, P. et. al. Neurotoxicity in chronic lithium poisoning. International Medicine Journal. 427-432. (2019)
- Howland, R. H. MD. Lithium: Underappreciated and Underused? Journal of Psychosocial Nursing and Mental Health Services. 13-17 (2007).
- Kleindienst, N., & Greil, W. Differential efficacy of lithium and carbamazepine in the prophylaxis of bipolar disorder: Results of the MAP study. Neuropsychobiology, 2-10 (2000)
- Ko, A. et al. Clinical characteristics associated with lithium use among adolescents with bipolar disorder. Journal of Child and Adolescent Psychopharmacology. 382-389 (2014).
- Lindsey, F. et al. Effect of lithium withdrawal on potassium-evoked dopamine release and tyrosine hydroxylase expression in the rat. The International Journal of Neuropsychopharmacology, 729-35. (2006)
- Malhi, G. S., & Tanious, M. Optimal frequency of lithium administration in the treatment of bipolar disorder. CNS Drugs, 289-98. (2011)
- Martin, A. Pharmacogenetics of lithium response in bipolar disorder. Journal of Psychiatry and Neuroscience. 154-158 (1999).
- Masiran, R. et al. Hypertensive bipolar: chronic lithium toxicity in patients taking ACE inhibitor. BMJ Case Reports. (2017)
- Sharma, V. Lithium in neuropsychiatry: the comprehensive guide. Canadian Journal of Psychiatry. 473 (2007).
- Shorter E. The history of lithium therapy. Bipolar Disorders. 4-9. (2009)
Credits
Written, Directed, and Featuring: Alexis Whiteside, Austii Burrell, Kyle Lorentzen, Samantha Hoffman
Scientific Research by: Alexis Whiteside, Austii Burrell, Kyle Lorentzen, Samantha Hoffman
Additional Sound Engineering: Cat Sawyer
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